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. Author manuscript; available in PMC: 2015 May 30.
Published in final edited form as: Vaccine. 2014 Apr 13;32(26):3187–3197. doi: 10.1016/j.vaccine.2014.04.002

Table 1.

Study experimental design and end-points

Experimenta Inoculated virus No. of NHPs Number of NHPs euthanized on indicated dpi
3 dpib 7 dpi 9/10 dpic 14 dpi 21 dpi
1 Mock 4 ND 1 1 1 1
1 WNV 12 3 3 6 N/A N/A
1 WN/DEN4Δ30 15 3 3 3 3 3
2 DEN4Δ30 12 ND 3 3 3 3
2 YF 17D 12 ND 3 3 3 3
a

Due to a large number of animals and safety concerns the study was done in two separate experiments which were executed in the same manner.

b

The 3 dpi time point was included in the first experiment. However, this time point was omitted in the second experiment due to relatively little informational value obtained.

c

Six remaining NHPs infected with WNV became uniformly severely ill by 9 dpi. However, five monkeys were euthanized on 9 dpi (during late afternoon) and one monkey on the following morning (10 dpi). Since the difference in the time of euthanasia between WNV-infected monkeys was less than 24 hours, and because the corresponding time of euthanasia/necropsy for all vaccine viruses was 10 dpi, this time point is referred as 9/10 dpi hereafter. N/A – not applicable (all WNV-infected monkeys were euthanized at 9/10 dpi). ND – not done.