Table 2.
Clinical course of infection in NHPs inoculated with WNV, WN/DEN4Δ30, DEN4Δ30, or YF 17D
| Inoculum | Clinical signsa | Clinical course on indicated dpi
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 0–3 | 4 | 5 | 6 | 7 | 8 | 9/10 | 14 | 21 | ||
| WNV | Gradeb | 0 100% |
2 22% |
2 22% |
3 33% |
3 56% |
3 83% |
4 100% |
N/A | N/A |
| Temperaturec | 39.9°C 25% |
40.8°C 56% |
40.7°C 78% |
40.8°C 50% |
N/A | N/A | ||||
| WN/DEN4Δ30 | Grade | 0 100% |
0 100% |
0 100% |
0 100% |
0 100% |
0 100% |
0 100% |
0 100% |
0 100% |
| Temperature | 39.4°C 27% |
39.7°C 33% |
39.7°C 22% |
|||||||
| DEN4Δ30 | Grade | 0 100% |
0 100% |
0 100% |
0 100% |
0 100% |
0 100% |
0 100% |
0 100% |
0 100% |
| Temperature | 39.6°C 8% |
40.4°C 78% |
||||||||
| YF 17D | Grade | 0 100% |
0 100% |
0 100% |
0 100% |
0 100% |
0 100% |
0 100% |
0 100% |
0 100% |
| Temperature | 39.8°C 25% |
39.6°C 11% |
39.8°C 22% |
40.2°C 67% |
||||||
a
Clinical signs were monitored and recorded as described in the Materials and Methods.
b
Neurological grades and percent of animals having the corresponding grade are shown.
c
If temperature was elevated (>39.3°C), the maximum recorded temperature and percent of animals with febrile reaction are shown. N/A – not applicable (all WNV-infected monkeys were euthanized at 9/10 dpi). Mock-inoculated animals (not shown) remained normal during the entire experiment (neurological grade 0; normal temperature).