TABLE 3.

Univariate and multivariate analysis of progression-free and overall survival

Factor	Progression-free survival		Overall survival
	p value, univariate	HR (95 % CI) and p value, multivariate	p value, univariate	HR (95 % CI) and p value, multivariate
Age (per year)	0.3	1.02 (1.0–1.04) p = 0.06	0.04	1.02 (1.0–1.04) p = 0.1
Female gender	0.6	0.97 (0.7–1.5) p = 0.9	0.02	0.9 (0.5–1.4) p = 0.6
Recurrent disease	0.002	1.6 (1.1–2.5) p = 0.02	0.3	1.2 (0.7–2.0) p = 0.5
Symptomatic  disease	0.1	1.2 (0.8–1.9) p = 0.4	0.2	0.9 (0.5–1.6) p = 0.7
High histologic  grade	<0.0001	2.7 (1.7–4.3) p < 0.0001	<0.0001	7.1 (3.9–13.0) p < 0.0001
Preoperative SPCI  (per point)	0.0002	1.08 (1.03–1.13) p = 0.0007	0.002	1.1 (1.04–1.2) p = 0.0009
Incomplete cytoreduction	<0.0001	1.9 (1.2–3.0) p = 0.005	<0.0001	1.3 (0.8–2.4) p = 0.3
Lymph node metastasis	<0.0001	1.9 (1.2–3.2) p = 0.01	<0.0001	1.0 (0.5–1.8) p = 1.0
Extensive CRS	0.09	0.9 (0.6–1.4) p = 0.5	0.8	0.9 (0.5–1.6) p = 0.7
Blood transfusion	0.09	1.5 (0.9–2.4) p = 0.1	0.03	1.4 (0.8–2.6) p = 0.3
Severe morbidity	0.5	0.9 (0.6–1.4) p = 0.8	0.09	0.9 (0.5–1.6) p = 0.7

HR hazard ratio, SPCI simplified peritoneal carcinomatosis index