Table 2.
Subgroup credibility criteria based on trial protocols that planned at least one subgroup analysis. Values are numbers (percentages) unless stated otherwise
| Credibility criteria | Sponsorship | All trials (n=252) | |
|---|---|---|---|
| Industry (n=195) | Investigator (n=57) | ||
| Clear hypothesis given?: | |||
| Yes | 7 (3.6) | 10 (17.5) | 17 (6.7) |
| No | 188 (96.4) | 47 (82.5) | 235 (93.3) |
| Direction of anticipated effect given?: | |||
| Yes | 3 (1.5) | 7 (12.3) | 10 (4.0) |
| No | 192 (98.5) | 50 (87.7) | 242 (96.0) |
| Interaction test planned?: | |||
| Yes | 69 (35.4) | 18 (31.6) | 87 (34.5) |
| No | 126 (64.6) | 39 (68.4) | 165 (65.5) |
| No of planned subgroup analyses: | |||
| Median (interquartile range) | 3 (1, 6) | 3 (1, 6) | 3 (1, 4) |
| Not reported (No of studies) | 18 (9.2) | 12 (21.1) | 30 (11.9) |