Table 4.
Overview of the thyroid function and auto-antibody titers of the 12 children who developed pathologic values during the course of IFN-α treatment Median (range)
| Treatment | TGA1 | TPOAb2 | TSH3 | FT34 | FT45 |
| Before | 29.0 (9.4-53.0) | 3.2 (0-41.0) | 2.7 (1.0-5.5) | 3.15 (2.1-5.3) | 1.2 (1.1-1.3) |
| During | 100.0 (8.0-141.0) | 82.5a (4-3 909) | 7.3a (1.7-76.0) | 2.12 (1.1-4.3) | 1 (0.4-1.3) |
| After | 40.0 (13-163.0) | 4.5 (0-289.0) | 2.2 (0.9-4.2) | 4.0 (2.0-5.3) | 1.1 (1.0-1.3) |
a
P < 0.05 vs before and after treatment.
1
Thyroglobulin antibody (normal range < 50 U/L);
2
Thyroid peroxidase antibody (normal range < 35 IU/mL);
3
Thyroid-stimulating hormone (normal range 0.3-4.2 mU/L);
4
Free triiodothyronine (normal range 1.8-4.6 ng/L);
5
Free thyroxine (normal range 7-19 ng/L).