Table II.

Risk factors for HDMTX-mediated renal toxicity and delayed MTX elimination.

	Grade 2-4 renal toxicity			Delayed MTX elimination
	Yes (%)	No (%)	p-value	Yes (%)	No (%)	p-value
Age*	60.8	51.3	<0.0001†	57.6	50	<0.0001†
Sex			0.0069^			<0.0001^
Male	78.3	58		73.7	52.4
Female	21.7	42		26.3	47.6
Baseline CrCl (mL/min)			0.0001#			<0.0001§
30-59	41.3	9		18.7	7
60-89	28.3	21.1		29.8	19.3
>90	30.4	69.9		51.5	73.7
MTX dose (g/m2)			0.0671§			0.1077^
1-2	13	7.1		2.3	5
>2-3	6.5	11.5		12.3	5.7
>3-4	69.6	54.7		45	54
>4-6	2.2	11.5		1.2	8.8
>6	8.7	15.3		39.2	26.5
PPI use	50	42.5	0.3237^	53.8	39.3	0.0011^

Key:

^{^}chi-square test,

^†two sample T test,

^#Wilcoxon two sample test,

^§row mean score test,

^*age values in mean years