Fig. 2.

Roles of ZFPs in white adipogenesis. The differentiation of multipotent mesenchymal precursors to mature adipocytes occurs in two stages. The first step of adipogenesis is the embryonic stem cell-derived MSCs transition to committed white preadipocytes. Then, upon hormone cocktail stimulation, committed white preadipocytes can become mature white adipocytes. During adipogenesis, various members of the ZFP family positively/negatively contribute to transcriptional control of preadipocyte differentiation as well as mesenchymal precursor cell linage determination. The solid arrow indicates possible direct transcriptional activation while the dashed arrow represents possible transcriptional suppression (red oval Pro-adipogenic ZFP; green oval Anti-adipogenic ZFP; and orange oval other adipogenic regulators)