Table 1.
Antiviral activity of BTA938 against influenza viruses by CPE inhibition
| Virus | EC50 (μM)a visual | EC50 (μM)a NR | SIb visual | SIb NR |
|---|---|---|---|---|
| H1N1 | ||||
| A/California/04/2009 | 0.36 ± 0.18 | 0.93 ± 0.58 | 2200 | 1667 |
| A/California/07/2009 | 0.25 ± 0.49 | 0.59 ± 0.77 | 2497 | 1887 |
| A/NWS/33 | <0.03 ± 0.00 | 0.04 ± 0.03 | >3100 | 2680 |
| A/Solomon Islands/03/2006 | 0.06 ± 0.05 | 0.46 ± 0.50 | 2343 | 427 |
| A/Mississippi/03/2001(H275Y) | 1.40 ± 0.49 | 2.10 ± 1.40 | >417 | >278 |
| H3N2 | ||||
| A/Panama/10/2007 | <0.03 ± 0.00 | <0.03 ± 0.00 | >3100 | >3100 |
| A/Victoria/3/75 | <0.03 ± 0.00 | 0.20 ± 0.33 | >3100 | 2360 |
| A/Wisconsin/67/2005 | 0.19 ± 0.23 | 0.26 ± 0.37 | 1958 | 1936 |
| H5N1 | ||||
| A/Duck/MN/1525/81 | <0.03 ± 0.00 | <0.03 ± 0.00 | >3100 | >3100 |
| A/Vietnam/1203/2004H | <0.03 ± 0.00 | <0.03 ± 0.00 | >3100 | >3100 |
| B | ||||
| Malaysia/2506/2004 | <0.03 ± 0.00 | <0.03 ± 0.00 | >3100 | >3100 |
Results are the means from five independent assays except for A/Panama/10/2007 and A/Victoria/3/75, which were tested independently four times, and A/Solomon Islands/03/2006, A/California/04/2009 and A/Mississippi/03/2001(H275Y), which were tested three times.
aDefined as the effective concentration of a compound required to reduce viral CPEs by 50%.
bDetermined by dividing values for CC50 (>95 μM for all replicates) by values for EC50. SI values <4.0, compound not active; SI values 4.0–9.9, compound slightly active; SI values 10–49.9, compound moderately active; and SI values >50, compound highly active.