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. 2014 Jul 16;9(7):e101223. doi: 10.1371/journal.pone.0101223

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Binge ethanol treatment (EtOH, 100 mM) of adult-age rat HEC slice cultures for 4 days as described in Methods significantly decreases the slice content of endogenous DHA (22:6n−3); supplementation of ethanol-binged cultures throughout with 25 µM DHA normalizes the DHA content. Binge ethanol treatment also increased the endogenous content of 22:5n−3, and DHA supplementation reduced the levels of this potential DHA precursor, as well as reduced the endogenous levels of ARA (22:4n−6). All other unsaturated fatty acids (not shown) were not significantly changed by binge ethanol treatment and DHA supplementation. *p<0.05 (n = 3/group, Tukey's t-test).