Table 3. Regression analysis of miRNA in non-recurrent and recurrent tumor relative to their normal adjacent tissue.

Recurrent Tumor (n = 8) compared to Non-Recurrent Tumor (n = 6):
miRNA	Fold Change	P	miRNA	Fold Change	P
hsa-let-7b	−48.7	0.027	hsa-miR-125a-3p	12.4	0.0001
hsa-miR-106b*	−9.7	0.017	hsa-miR-589	4.6	0.0015
hsa-miR-187	−7.8	0.036	hsa-miR-450a	6.2	0.0044
hsa-miR-650	−4.7	0.049	hsa-miR-211	13.8	0.0117
hsa-miR-886-5p	−1.7	0.048	hsa-miR-139-3p	10.9	0.0128

After normalizing miRNA expression in each adenocarcinoma to endogenous control RNU48, they were normalized to the expression in the corresponding matched adjacent normal control lung tissue. Limma [9] was then used to identify differentially expressed miRNA between tumors that did and did not recur and calculate p values.