Table 1.
Baseline Characteristics of the Cohort Stratified by the Family History of HCC and HBsAg
| Subgroup |
|||||
|---|---|---|---|---|---|
| Characteristics | All | Family history of HCC negative and HBsAg negative | Family history of HCC positive and HBsAg negative | Family history of HCC negative and HBsAg positive | Family history of HCC positive and HBsAg positive |
| N | 22,472 | 18,194 | 347 | 3751 | 180 |
| HCC cases, n | 374 | 100 | 2 | 246 | 26 |
| Mean age ± SD, y | 47.2 ± 10.0 | 47.5 ± 10.1 | 45.5 ± 9.4 | 45.9 ± 9.8 | 45.4 ± 9.2 |
| Mean BMI ± SD, kg/m2 a | 24.0 ± 3.4 | 24.0 ± 3.4 | 24.0 ± 3.5 | 24.0 ± 3.4 | 23.7 ± 3.3 |
| Alcohol use, n (%)b | |||||
| No | 19,999 (89.2) | 16,242 (89.5) | 302 (87.0) | 3298 (88.1) | 157 (87.7) |
| Yes | 2422 (10.8) | 1908 (10.5) | 45 (13.0) | 447 (11.9) | 22 (12.3) |
| Smoking, n (%)c | |||||
| No | 15,917 (71.0) | 13,025 (71.7) | 245 (70.6) | 2528 (67.5) | 119 (66.1) |
| Yes | 6517 (29.1) | 5134 (28.3) | 102 (29.4) | 1220 (32.6) | 61 (33.9) |
| ALT level, U/L | |||||
| <45 | 21,859 (97.3) | 17,815 (97.9) | 339 (97.7) | 3537 (94.3) | 168 (93.3) |
| ≥45 | 613 (2.7) | 379 (2.1) | 8 (2.3) | 214 (5.7) | 12 (6.7) |
| Diabetesd | |||||
| No | 21,867 (97.6) | 17,693 (97.5) | 341 (98.3) | 3657 (97.7) | 176 (97.8) |
| Yes | 545 (2.4) | 448 (2.5) | 6 (1.7) | 87 (2.3) | 4 (2.2) |
| Genotype | |||||
| B | 1923 (66.5) | N/A | N/A | 1844 (66.9) | 79 (57.7) |
| BC and C | 970 (33.5) | 912 (33.1) | 58 (42.3) | ||
| Precore mutant (1896 G/A) | |||||
| Wild type | 703 (38.2) | N/A | N/A | 672 (38.3) | 31 (35.6) |
| Mutant + mixed type | 1138 (61.8) | 1082 (61.7) | 56 (64.4) | ||
| BCP mutant (1762/1764) | |||||
| Wild type | 1031 (56.9) | N/A | N/A | 990 (57.3) | 41 (48.8) |
| Mutant + mixed type | 782 (43.1) | 739 (42.7) | 43 (51.2) | ||
| HBeAg | |||||
| Seronegative | 3155 (84.5) | N/A | N/A | 3014 (84.7) | 141 (81.5) |
| Seropositive | 577 (15.5) | 545 (15.3) | 32 (18.5) | ||
| HBV DNA level, copies/mL | |||||
| HBV DNA level, <10,000 | 2035 (55.7) | N/A | N/A | 1941 (55.7) | 94 (54.7) |
| HBV DNA level, ≥10,000 | 1621 (44.3) | 1543 (44.3) | 78 (45.4) | ||
ALT, alanine aminotransferase; BCP, basal core promoter mutation; BMI, body mass index.
a
Fifty-three subjects were excluded because of missing data on body mass index.
b
Fifty-one subjects were excluded because of missing data on alcohol use.
c
Thirty-eight subjects were missing data on smoking.
d
Sixty subjects were missing data on history of diabetes.