Table 3.
Crude and Multivariate-Adjusted HRs of Incident HCC
| Characteristic | All (N = 22,472) |
HBsAg negative (n = 18,541) |
HBsAg positive (n = 3931) |
HBsAg-positive subset (n = 1767) |
||
|---|---|---|---|---|---|---|
| Crude HR (95% CI) | Age/sex-adjusted HR (95% CI) | Multivariate adjusted HR (95% CI) | Multivariate adjusted HR (95% CI) | Multivariate adjusted HR (95% CI) | Multivariate adjusted HR (95% CI) | |
| Sex | ||||||
| Female | Referent | Referent | Referent | Referent | Referent | Referent |
| Male | 3.18 (2.51-4.02) | 2.47 (1.95-3.13) | 2.09 (1.58-2.77) | 1.05 (0.61-1.80) | 2.85 (2.01-4.04) | 3.02 (1.99-4.58) |
| Age, y | 1.06 (1.05-1.08) | 1.08 (1.06-1.09) | 1.08 (1.07-1.09) | 1.09 (1.06-1.11) | 1.08 (1.06-1.09) | 1.09 (1.07-1.11) |
| BMI, kg/m2 | 1.05 (1.02-1.08) | 1.04 (1.01-1.07) | 1.05 (0.99-1.11) | 1.04 (1.00-1.08) | 1.04 (1.00-1.09) | |
| Smoking habit | ||||||
| No | Referent | Referent | Referent | Referent | Referent | |
| Yes | 2.07 (1.68-2.54) | 1.11 (0.87-1.42) | 1.42 (0.83-2.45) | 1.06 (0.81-1.38) | 1.22 (0.88-1.71) | |
| Alcohol consumption | ||||||
| No | Referent | Referent | Referent | Referent | Referent | |
| Yes | 2.32 (1.81-2.98) | 1.46 (1.12-1.91) | 1.32 (0.75-2.34) | 1.50 (1.11-2.04) | 1.26 (0.86-1.84) | |
| Diabetes | ||||||
| No | Referent | Referent | Referent | Referent | Referent | |
| Yes | 1.12 (0.98-1.28) | 1.19 (1.02-1.39) | 1.20 (0.99-1.46) | 1.17 (0.92-1.49) | 1.08 (0.82-1.44) | |
| ALT level, U/L | ||||||
| ≤45 | Referent | Referent | Referent | Referent | Referent | |
| >45 | 6.32 (4.73-8.46) | 3.66 (2.72-4.94) | 3.19 (1.46-6.95) | 3.65 (2.64-5.05) | 2.17 (1.48-3.18) | |
| Genotypea | ||||||
| B | Referent | Referent | ||||
| BC and C | 2.53 (1.95-3.28) | 1.88 (1.37-2.60) | ||||
| Precore mutant (1896 G/A)a | ||||||
| Wild type | Referent | Referent | ||||
| Mutant + mixed type | 0.49 (0.37-0.65) | 0.49 (0.36-0.67) | ||||
| BCP mutant (1762/1764)a | ||||||
| Wild type | Referent | Referent | ||||
| Mutant + mixed type | 2.47 (1.83-3.32) | 1.78 (1.29-2.45) | ||||
| Family history of HCC/HBsAg | ||||||
| No/HBsAg negative | Referent | Referent | Referent | Referent | ||
| Yes/HBsAg negative | 1.04 (0.26-4.22) | 1.26 (0.31-5.09) | 1.29 (0.32-5.24) | 1.26 (0.31-5.14) | ||
| No/HBsAg positive | 12.32 (9.76-15.54) | 13.38 (10.59-16.91) | 13.04 (10.28-16.54) | Referent | Referent | |
| Yes/HBsAg positive | 28.33 (18.40-43.62) | 32.79 (21.26-50.58) | 32.33 (20.78-50.30) | 2.46 (1.63-3.72) | 2.33 (1.40-3.88) | |
ALT, alanine aminotransferase; BCP, basal core promoter mutation; BMI, body mass index.
a
Fifty-three subjects were excluded because of missing data on body mass index.