Table 4.

Multivariate-Adjusted HRs of HCC by Family History Status and the Stage of HBV Infection Including HBsAg, HBeAg, and HBV DNA Level

Characteristic	Age/sex-adjusted HR (95% CI)	All (N = 22,472)	HBsAg positive only (n = 3931)
		Multivariate adjusted HR (95% CI)	Multivariate adjusted HR (95% CI)
Sex, male vs female	2.16 (1.69-2.75)	1.78 (1.33-2.39)	2.36 (1.63-3.41)
Age, y	1.09 (1.08-1.11)	1.09 (1.08-1.11)	1.10 (1.09-1.11)
BMI, kg/m2		1.05 (1.01-1.08)	1.05 (1.01-1.09)
Smoking habit, yes vs no		1.25 (0.97- 1.61)	1.24 (0.93-1.65)
Alcohol consumption, yes vs no		1.40 (1.06-1.86)	1.41 (1.03-1.94)
Diabetes, yes vs no		1.12 (0.96-1.31)	1.06 (0.83-1.36)
ALT level, >45 vs ≤45 U/L		2.23 (1.62-3.06)	2.04 (1.45-2.89)
Family history of HCC/HBsAg/HBeAG/HBV DNA level
No/HBsAg negative	Referent	Referent	N/A
Yes/HBsAg negative	1.30 (0.32-5.26)	1.31 (0.32-5.33)	N/A
No/HBsAg positive/HBeAg negative/HBV DNA <10,000 copies/mL	3.75 (2.57-5.47)	3.87 (2.65-5.65)	Referent
Yes/HBsAg positive/HBeAg negative/HBV DNA <10,000 copies/mL	9.27 (3.41-25.20)	9.42 (3.46-25.63)	2.44 (0.87-6.84)
No/HBsAg positive/HBeAg negative/HBV DNA ≥ 10,000 copies/mL	17.22 (12.94-22.91)	17.37 (13.02-23.18)	4.43 (3.02-6.50)
Yes/HBsAg positive/HBeAg negative/HBV DNA ≥10,000 copies/mL	36.62 (17.80-75.35)	39.04 (18.91-80.61)	9.90 (4.59-21.37)
No/HBsAg positive/HBeAg positive	60.21 (44.79-80.95)	52.33 (38.36-71.37)	13.91 (9.31-20.77)
Yes/HBsAg positive/HBeAg positive	178.38 (96.83-328.63)	174.61 (92.16-330.83)	45.52 (22.86-90.63)

NOTE. We did not adjust for genotype and mutants because these data were available only in patients with a DNA level greater than 10,000.

ALT, alanine aminotransferase; BMI, body mass index.