Table 5.

Multivariate-Adjusted HRs of HCC According to the Number of First-Degree Relatives With HCC

Characteristic	All with positive family history (N = 527)	HBsAg positive only (N = 180)
	Age/sex-adjusted HR (95% CI)	Multivariate adjusted HR (95% CI)
Sex, male vs female	2.40 (0.86-6.68)	1.81 (0.56-5.88)
Age, y	1.05 (1.01-1.10)	1.06 (1.02-1.10)
BMI, kg/m2	0.98 (0.88-1.10)	0.97 (0.84-1.12)
Smoking habit, yes vs no	1.26 (0.49-3.25)	1.76 (0.65-4.74)
Alcohol consumption, yes vs no	0.62 (0.17-2.20)	0.78 (0.21-2.94)
Diabetes, yes vs no	1.79 (0.24- 13.59)	1.44 (0.18-11.80)
ALT level, >45 vs ≤45 U/L	9.16 (3.53-23.76)	6.71 (2.36-19.02)
First-degree relatives with HCC, n
1	1.0	1.0
≥1	1.83 (0.53-6.32)	1.57 (0.43-5.72)

NOTE. We could not look at genotype or mutant data because there were no data for more than 80% of these individuals because the majority of people were HBsAg negative. There were only 2 HCC cases among HBsAg-negative participants, so it was not possible to perform this analyses in this subset.

ALT, alanine aminotransferase; BMI, body mass index.