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. 2014 Jun 5;53(27):4476–4487. doi: 10.1021/bi500491w

Figure 4.

Figure 4

(A) Cartoon of WT hBChE gorge and “main door” apertures in the presence or absence of nerve agent model compounds. hBChE active site residues (i.e., S198, E325, and H438) are indicated. D is the distance of the “main door” aperture. (B) Structural model of WT hBChE with eight residues in the gorge highlighted (i.e., N68, Q119, A277, L286, V288, A328, F329, and Y332). Key amino acids in the protein are colored cyan. Non-carbon atoms are colored blue (nitrogen), red (oxygen), yellow (sulfur), and white (polar hydrogens) in the depiction.