Table 2. Concentrations (µM) and levels of 11 small molecules used with imatinib in the combinatorial drug searches.
Level\Drug | A7 | A12 | A15 | C16 | E03 | I22 | P15 | ABT263 | Axitinib | 17AAG | PD325901 |
1 | 0.025 | 0.125 | 0.05 | 0.0125 | 0.0125 | 0.00125 | 0.125 | 0.125 | 0.025 | 0.0025 | 0.005 |
2 | 0.05 | 0.25 | 0.1 | 0.025 | 0.025 | 0.0025 | 0.25 | 0.25 | 0.05 | 0.005 | 0.01 |
3 | 0.1 | 0.5 | 0.15 | 0.05 | 0.05 | 0.005 | 0.5 | 0.5 | 0.25 | 0.0125 | 0.025 |
4 | 0.25 | 1 | 0.25 | 0.1 | 0.1 | 0.01 | 1 | 1 | 0.5 | 0.025 | 0.05 |
Level\Drug (Adjusted) | A7 | A12 | A15 | C16 | E03 | I22 | P15 | ABT263 | Axitinib | 17AAG | PD325901 |
1 | 0.025 | 0.125 | 0.05 | 0.0125 | 0.0125 | 0.00125 | 0.125 | 0.0125 | 0.025 | 0.0025 | 0.005 |
2 | 0.05 | 0.25 | 0.1 | 0.025 | 0.025 | 0.0025 | 0.25 | 0.05 | 0.05 | 0.005 | 0.01 |
3 | 0.1 | 0.5 | 0.15 | 0.05 | 0.05 | 0.005 | 0.5 | 0.125 | 0.25 | 0.0125 | 0.025 |
4 | 0.25 | 1 | 0.25 | 0.1 | 0.1 | 0.01 | 1 | 0.25 | 0.5 | 0.025 | 0.05 |
5 | 0.3 | 1.5 | 0.35 | 0.125 | 0.125 | 0.0125 | 1.25 | 0.5 | 0.55 | 0.03 | 0.06 |
6 | 0.35 | 1.75 | 0.45 | 0.175 | 0.175 | 0.0175 | 1.75 | 1 | 0.8 | 0.0425 | 0.085 |