Table 2. BCSS in multivariate analysis (Cox regression) according to TTSP genotypes.
| Genotype | n | B (SE) | Wald | HR (95% CI) | P value | |
| TMPRSS1 | ||||||
| rs12151195 | 0.008 a | |||||
| TT | 316 | ref. | ||||
| TC | 57 | 0. 690 (0.252) | 7.515 | 1.99 (1.22–3.26) | 0.006 | |
| CC | 1 | 1.806 (1.056) | 2.922 | 6.08 (0.77–48.2) | 0.087 | |
| TC+CC | 58 | 0.712 (0.248) | 8.226 | 2.04 (1.25–3.32) | 0.004 | |
| rs12461158 | ||||||
| GG | 224 | ref. | ||||
| GA+AA | 144 | −0.519 (0.232) | 5.001 | 0.60 (0.38–0.94) | 0.025 | |
| TMPRSS2 | ||||||
| rs2276205 | ||||||
| AA | 270 | ref. | ||||
| AG+GG | 92 | −0.549 (0.267) | 4.206 | 0.58 (0.34–0.98) | 0.040 | |
| TMPRSS3 | ||||||
| rs3814903 | 0.046 a | |||||
| GG | 149 | ref. | ||||
| GT | 174 | 0.478 (0.234) | 4.166 | 1.61 (1.02–2.55) | 0.041 | |
| TT | 42 | −0.135 (0.351) | 0.147 | 0.87 (0.44–1.74) | 0.74 | |
| TMPRSS7 | ||||||
| rs2399403 | 0.047 a | |||||
| TT | 317 | ref. | ||||
| TC | 52 | 0.645 (0.261) | 6.101 | 1.91 (1.14–3.18) | 0.014 | |
| CC | 4 | 0.140 (0.731) | 0.037 | 1.15 (0.27–4.82) | 0.84 | |
| TC+CC | 56 | 0.585 (0.250) | 5.450 | 1.79 (1.10–2.93) | 0.020 | |
| Combined risk allele variable | ||||||
| 0.006 a | ||||||
| 1–3 alleles | 84 | ref. | ||||
| 4–5 alleles | 219 | 0.675 (0.324) | 4.328 | 1.96 (1.04–3.71) | 0.037 | |
| 6–8 alleles | 49 | 1.193 (0.375) | 10.13 | 3.30 (1.58–6.88) | 0.001 |
a
overall P value.
Significant P values bolded.
Note: Age, tumor grade, histological type, tumor size, nodal status, ER status, and HER2 status were included in the analysis.
Abbreviations: B (SE), coefficient with standard error, and ref., reference genotype.