Figure 4. ROR ICD is not required for suppression of canonical Wnt signaling. ROR1 and ROR2 inhibit Wnt3a-stimulated transcription of a luciferase reporter from a Lef/Tcf promoter and this activity is enhanced by Wnt5a ligand.

The ROR1 or ROR2 ECD alone can suppress canonical Wnt signaling when anchored to the plasma membrane. The luciferase reporter data presented in this figure are representative of at least three independent experiments and are normalized to untreated vector transfected cells. Error bars represent standard error.