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Synthesis of glibenclamidecarboxy-derivative 6.(i) Boc-glycinol, PPh3, DEAD, THF, 0 °C to room temp. (ii) 2.0M NaOH, methanol, room temp. (iii) (a) ethyl chloroformate, NMM, DMF, 0 °C. (b) 4-(2-aminoethyl)benzenesulfonamide, DMF, 0 °C to room temp. (iv) cyclohexylisocyanate, CuI, DMF, room temp. (v) TFA, room temp. (vi) diglycolic anhydride, DMF, room temp.
