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Synthesis of Cy5 labelled GLP-1/Glb 9. (i) Fmoc/tBu solid phase synthesis, ε-amine of Lys26 protected with Aloc. (ii) Pd(0) tetrakis Ph3P, N,N-dimethyl barbituric acid, DCM, 30 min., room temp. (iii) Fmoc-PEGO, DIC, DCM, room temp. (iv) Fmoc/tBu solid phase synthesis, Pro-Gly repeats and Cys(Trt). (v) 6, DIC, HOBt, room temp, overnight. (vi) TFA, scavenges, 4 hrs, room temp. (vi) Cy5-maleimide, DMF, room temp.
