Figure 1. (A) ERM/ETV5 protein expression by IHC. Left, negative sample of normal endometrial epithelium. Center, EEC-positive sample. Right, brain tissue (positive control). (B) ERM/ETV5 mRNA expression by RT-qPCR, normalized to β-actin, in EEC and normal endometrial samples, according to protein expression score by IHC. ERM/ETV5 mRNA expression is higher in scored 3+ cases in comparison with normal endometrial epithelium and with 1+ scored samples (P = 0.0007). (C) ERM/ETV5 mRNA expression by RT-qPCR, normalized to β-actin, in EEC samples of patients with different tumor stages and in normal endometrial samples. ERM/ETV5 mRNA expression is higher in IA stage EEC in comparison with other EEC stage or normal endometrial epithelium samples (P < 0.0001).