Figure 1. Eukaryotic translation of mRNA. Methylated 5′ cap, 5′m; translation initiation site, TIS (a motif that also includes the start codon); stop codon; ribosomal subunits, ovals; protein-coding ORF, green rectangle; protein, squiggle; polyA, AAA. The asterisk denotes factors that complete the ribosomal preinitiation complex.