Figure 6. Schematic of stress-induced translation of ATF4. After translating uORF1, under non-stressed conditions, the 40S subunit (small oval) quickly reloads with eIF2-GTP, Met-tRNA, and other eIFs (red asterisk) and reinitiates translation at uORF2. Under stress, the 40S subunit is not reloaded until later, reinitiating translation at ATF4.