TABLE 3.
Summaries of the effects of pre-enhancement positioning on CTp parameter values. The analyses considered parameter values after acquisition durations of 220s and 360s. The mean percentage change from pre-enhancement setpoint (T1=0s) and the corresponding 95% confidence intervals derived from the mixed-effects inference are provided in the table.
| 220s | 360s | ||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Tumor | Normal liver | Tumor | Normal liver | ||||||
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| CTp parameter |
T1 time relative to T1=0s (seconds) |
Mean (%) |
95% CI (%) |
Mean (%) |
95% CI (%) |
Mean (%) |
95% CI (%) |
Mean (%) |
95% CI (%) |
| BF | −2.0 | −1.1 | −4.9 – 2.8 | 0.4 | −2.1 – 2.9 | −1.2 | −5.0 – 2.7 | 0.5 | −2.0 – 3.0 |
| −1.0 | −0.1 | −4.0 – 3.8 | 0.2 | −2.3 – 2.7 | −0.1 | −3.9 – 3.9 | 0.4 | −2.1 – 2.9 | |
| −0.5 | −0.1 | −3.9 – 3.9 | −1.0 | −3.5 – 1.5 | 0.0 | −3.9 – 3.9 | −1.0 | −3.5 – 1.5 | |
| +0.5 | 0.6 | −3.3 – 4.5 | 1.0 | −1.5 – 3.5 | 0.6 | −3.2 – 4.6 | 1.0 | −1.5 – 3.5 | |
| +1.0 | 0.6 | −3.3 – 4.5 | 1.1 | −1.5 – 3.6 | 0.7 | −3.2 – 4.6 | 1.1 | −1.4 – 3.7 | |
| +2.0 | 0.9 | −2.9 – 4.9 | 2.5 | 0.0 – 5.1 | 1.0 | −2.9 – 4.9 | 2.6 | 0.0 – 5.2 | |
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| BV | −2.0 | 4.3 | 0.2 – 8.8 | 3.6 | 1.4 – 6.0 | 4.3 | 0.0 – 8.9 | 2.9 | 0.6 – 5.3 |
| −1.0 | 3.6 | −0.5 – 8.1 | 1.9 | −0.4 – 4.2 | 3.6 | −0.5 – 8.1 | 2.1 | −0.2 – 4.4 | |
| −0.5 | 1.6 | −2.4 – 6.0 | 0.9 | −1.4 – 3.2 | 1.8 | −2.2 – 6.1 | 0.8 | −1.5 – 3.0 | |
| +0.5 | −2.3 | −6.5 – 1.8 | −1.8 | −4.0 – 0.4 | −2.1 | −6.3 – 2.0 | −1.7 | −4.0 – 0.5 | |
| +1.0 | −3.6 | −7.8 – 0.5 | −3.4 | −5.6 – −1.1 | −3.5 | −7.7 – 0.6 | −3.3 | −5.6 – −1.1 | |
| +2.0 | −8.0 | −12.7 – −3.9 | −5.4 | −7.7 – −3.1 | −7.9 | −12.7 – −3.8 | −5.5 | −7.9 – −3.3 | |
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| MTT | −2.0 | 5.4 | 3.1 – 7.9 | 4.0 | 1.8 – 6.3 | 5.6 | 3.3 – 8.1 | 3.1 | 1.0 – 5.3 |
| −1.0 | 3.9 | 1.6 – 6.4 | 1.8 | −0.4 – 4.0 | 4.0 | 1.7 – 6.4 | 1.5 | −0.5 – 3.7 | |
| −0.5 | 2.1 | −0.2 – 4.5 | 2.0 | −0.2 – 4.3 | 2.3 | 0.1 – 4.6 | 1.7 | −0.3 – 3.9 | |
| +0.5 | −2.3 | −4.6 – −0.1 | −1.7 | −3.9 – 0.5 | −2.0 | −4.2 – 0.2 | −2.0 | −4.0 – 0.1 | |
| +1.0 | −4.6 | −6.9 – −2.3 | −3.3 | −5.5 – −1.1 | −4.4 | −6.7 – −2.1 | −3.5 | −5.6 – −1.4 | |
| +2.0 | −10.1 | −12.6 – −7.7 | −6.7 | −8.9 – −4.5 | −10.0 | −12.5 – −7.7 | −7.1 | −9.2 – −5.1 | |
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| PS | −2.0 | 3.5 | 1.4 – 5.8 | 1.6 | 0.8 – 2.5 | 3.5 | 1.4 – 5.7 | 1.6 | 0.7 – 2.6 |
| −1.0 | 1.8 | −0.3 – 3.9 | 1.0 | 0.2 – 1.9 | 1.7 | −0.3 – 3.9 | 1.0 | 0.1 – 1.9 | |
| −0.5 | 0.8 | −1.2 – 3.0 | 0.7 | −0.2 – 1.6 | 0.8 | −1.2 – 2.9 | 0.7 | −0.2 – 1.6 | |
| +0.5 | −1.0 | −3.0 – 1.1 | −0.9 | −1.8 – 0.0 | −1.0 | −3.1 – 1.1 | −1.0 | −1.9 – −0.1 | |
| +1.0 | −1.8 | −3.9 – 0.2 | −1.2 | −2.0 – −0.3 | −1.8 | −3.9 – 0.3 | −1.4 | −2.3 – −0.5 | |
| +2.0 | −3.2 | −5.3 – 1.1 | −2.1 | −3.0 – −1.3 | −3.1 | −5.3 – −1.1 | −2.4 | −3.3 – −1.5 | |
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| HAF | −2.0 | −5.9 | −9.8 – −2.0 | −5.3 | −13.0 – 1.8 | −5.8 | −9.6 – −1.9 | −5.2 | −12.9 – 1.8 |
| −1.0 | −3.7 | −7.6 – 0.2 | −5.4 | −13.2 – 1.6 | −3.7 | −7.5 – 0.2 | −5.8 | −13.5 – 1.3 | |
| −0.5 | −1.7 | −5.6 – 2.2 | −1.4 | −8.6 – 5.9 | −1.9 | −5.7 – 2.1 | −1.4 | −8.7 – 6.0 | |
| +0.5 | 2.9 | −1.0 – 7.0 | 3.2 | −3.9 – 11.3 | 2.9 | −1.0 – 6.9 | 3.2 | −3.8 – 11.3 | |
| +1.0 | 4.2 | 0.3 – 8.3 | 7.4 | 0.1 – 16.3 | 4.1 | 0.2 – 8.2 | 7.2 | 0.1 – 16.2 | |
| +2.0 | 10.3 | 6.2 – 14.8 | 14.8 | 6.8 – 26.0 | 10.3 | 6.2 – 14.7 | 14.9 | 6.8 – 26.0 | |