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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: J Cardiovasc Transl Res. 2014 May 13;7(5):483–493. doi: 10.1007/s12265-014-9563-7

Fig. 4. The HF-band power segment of the BBF in the QRS-wave is reduced in Hum CHGA 19 mice.

Fig. 4

The broadband frequency area (BBF) of the QRS wave segments were further analyzed. The BBF comprises of the sympathetic LF (low frequency) and the parasympathetic HF (high frequency) areas, indicative of efferent activity at the sinus node. (a) An illustration of power-frequency of QRS-wave plot: These plots were derived from actual experiments. Note in HumCHGA19 mice the frequency shift of peak power in the HF range along with a decrease in total power across the frequency range. (b) The QRS-wave segmented into average % of time spent in HF: Percentage of HF (80-300 Hz) area in the total BBF in the QRS-wave was significantly reduced in HumCHGA19 mice compared to WT and HumCHGA31 mice (##, ** p< 0.01). Analyzed data of the QRS spectra had the following characteristics: HumCHGA19- BBF area: 0.52, 0-80 Hz: 0.21, 80-300 Hz: 0.31 (HF: 59.61% of BBF), HumCHGA31- BBF area: 2.038, 0-80 Hz: 0.53, 80-300 Hz: 1.50 (HF: 73.60% of BBF) and WT- BBF area: 2.00, 0-80 Hz: 0.49, 80-300 Hz: 1.51 (75.5% of BBF). The area values are in arbitrary unit (au). (c) Influence of HR on the HF (80-300 Hz) part of BBF (0-300 Hz) spectral area: Bar graph shows that the fraction of HF area in the BBF of HumCHGA19 significantly lowered as compared to mice in other groups, as the sinus cycle length decreases (##, ** p< 0.01)