. Author manuscript; available in PMC: 2015 Aug 1.

Published in final edited form as: Ther Drug Monit. 2014 Aug;36(4):544–548. doi: 10.1097/FTD.0000000000000050

Table 3.

Classification and potential risks associated with interacting drugs.

Drug Class	Classification of Drug Interaction^*	Potential Risk
Aminoglycoside antibiotics	Major	Possess neuromuscular blocking activity; Potential additive pharmacological effect
Antacids / laxatives	Moderate	May increase the risk of magnesium toxicity
Calcium channel blockers	Moderate	May result in hypotension and neuromuscular blockade
Corticosteroids	Moderate	Potential for significant loss of electrolytes; Potentiates the risk of hypokalemia
Diuretics	Moderate	May potentiate the pharmacological effects of diuretics
Neuromuscular-blocking agents	Moderate	Magnesium salts may enhance the effects of neuromuscular-blocking agents
Vitamin D analogs	Moderate	Increases the risk of hypermagnesemia; Potential additive pharmacological effect

Moderate and major drug-drug interactions were classified according to the drug interaction classification featured on Drugs.com.¹⁸ Data sources include Micromedex^™, Cerner Multum^™, Wolters Kluwer^™ and others.