Table 6.
Endomyocardial biopsy and coronary angiography results of acute allograft dysfunction patients grouped by antibody mediated rejection and donor specific antibody status
| Variable | AMR+ DSA+ (N=4) | AMR+ DSA- (N=2) | AMR- DSA- (N=4) |
|---|---|---|---|
| Endomyocardial biopsy | |||
| C4d stain positive | 4 (100%) | 2 (100%) | 0 |
| CD68 stain positive | 2 (50%) | 0 | 0 |
| Macrophage infiltration | 2 (50%) | 1 (50%) | 0 |
| Endothelial swelling | 1 (25%) | 1 (50%) | 0 |
| AMR grade* | |||
| 0 | 0 | 0 | 4 (100%) |
| 1 | 4 (100%) | 2 (100%) | 0 |
| ACR grade* | |||
| 0R | 2 (50%) | 1 (50%) | 4 (100%) |
| 1R | 2 (50%) | 1 (50%) | 0 |
| 2R | 0 | 0 | 0 |
| 3R | 0 | 0 | 0 |
| Transplant rejection score | 0.4 ± 0.2 | 0.4 ± 0.2 | 0.3 ± 0.2 |
| Coronary angiography | |||
| Normal coronary arteries | 2 (50%) | 1 (50%) | 1 (25%) |
| Coronary atherosclerosis* | |||
| Mild | 2 (50%) | 1 (50%) | 3 (75%) |
| Moderate | 0 | 0 | 0 |
| Severe | 0 | 0 | 0 |
| Intravascular ultrasound performed | 1 (25%) | 0 | 1 (25%) |
| †Significant CAV | 0 | 0 | 0 |
*
According to International Society for Heart and Lung Transplantation criteria.
†
Coronary stenosis of ≥70% and/or distal pruning of secondary side branches. Data are presented as mean ±standard deviation for continuous data or as frequency (percentage) for categorical data. AAD-acute allograft dysfunction, ACR-acute cellular rejection, AMR-antibody mediated rejection, CAV-coronary allograft vasculopathy, DSA-donor specific antibody.