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SIRT3 regulates colon cancer cells proliferation, migration, invasion, and apoptosis. Transfection of si-SIRT3 resulted in decreased cell proliferation (a), migration (b), and invasion (c) in the SW 480 and DLD-1 cells. In contrast to the above mentioned changes, the apoptosis was dramatically increased by SIRT3 inhibition in two cell lines (d).
