Table 1.
Association of clinicopathological factors in colorectal cancer patients and expression of mir-133a in tumor tissue. A higher ΔΔ value indicates lower expression; positive values represent downregulation.
| Variables | Patients, n | MiR-133a expression | P value† |
|---|---|---|---|
| (n = 125)a | Mean ΔΔ value ± SD | ||
| Age | 0.938 | ||
| ≤65 | 36 | 4.440 ± 0.4927 | |
| >65 | 89 | 4.488 ± 0.3301 | |
| Gender | 0.977 | ||
| Male | 73 | 4.517 ± 0.3569 | |
| Female | 51 | 4.501 ± 0.4332 | |
| Dukes | 0.0481∗ | ||
| A, B | 42 | 5.139 ± 0.5392 | |
| C, D | 36 | 3.716 ± 0.4348 | |
| Tumor size | 0.2643 | ||
| <5 cm | 68 | 4.739 ± 0.3548 | |
| ≥5 cm | 55 | 4.124 ± 0.4228 | |
| Histological type | 0.3664 | ||
| Well, moderate | 78 | 4.681 ± 0.3499 | |
| Poor, mucinous | 5 | 3.395 ± 1.172 | |
| Depth of invasion | 0.2158 | ||
| T1, T2 | 16 | 5.400 ± 0.7513 | |
| T3, T4 | 100 | 4.352 ± 0.3146 | |
| TNM stage | 0.0031∗ | ||
| I, II | 60 | 5.316 ± 0.3887 | |
| III, IV | 62 | 3.667 ± 0.3835 | |
| Location | 0.9658 | ||
| Colon | 90 | 4.527 ± 0.3259 | |
| Rectum | 32 | 4.554 ± 0.5298 | |
| Lymph node metastasis | 0.0595 | ||
| Absent | 68 | 4.926 ± 0.3629 | |
| Present | 55 | 3.893 ± 0.4034 | |
| Distant metastasis | 0.0020∗ | ||
| Absent | 95 | 4.983 ± 0.3188 | |
| Present | 28 | 2.932 ± 0.5104 |
aThe total number of cases may be less than 125 as some information was unavailable.
† P values are based on Student's t-test.
SD: standard deviation; *P < 0.05.