Fig. 4.

Combination ganetespib plus capecitabine treatment confers superior antitumor efficacy in CRC xenografts. Over a 3 week cycle, mice bearing established HCT 116 xenografts (n = 8/group) were i.v. dosed with 150 mg/kg ganetespib 1×/week or p.o dosed with 400 mg/kg capecitabine daily for 14 consecutive days, either alone or in combination. % T/C values are indicated to the right of each growth curve and the error bars are the SEM. Combination ganetespib + capecitabine treatment resulted in significant tumor regression (*, p < 0.05)