Figure W4.

Immune cell counts in the colon of mice at 1 week after DSS treatment. In the lamina propria of colonic mucosa, uPA^−/− + DSS mice have more (A) neutrophils (MPO +) and (B) less T-lymphocytes (CD3 +) in comparison with WT + DSS mice. (C) In mucosal lymphoid follicles, uPA deficiency associates with increased numbers of T-lymphocytes in both DSS-treated and non-treated group comparisons. (D) Foxp3 + Treg counts in ulcerative lesions and (E) GALT yield a non-statistically significant difference between uPA^−/− + DSS and WT + DSS mice. uPA^−/− untreated control mice, however, have significantly more Treg than the WT untreated mice in the GALT. Numbers on the y-axis of bar graphs correspond to the means ± SEM of cell counts.