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. 2014 Jul 17;5:131. doi: 10.3389/fneur.2014.00131

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Copyright © 2014 Tousseyn, Dupont, Goffin, Sunaert and Van Paesschen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Determination of test outcome. EEG-spikes = spike-time course based on manually indicated interictal spikes. Regressor = spike-time course of patient convolved with canonical hemodynamic response function. Areas of suprathreshold BOLD changes overlapping the ictal onset zone in patients were considered as true positives and if no overlap was found, they were treated as false negatives. Suprathreshold BOLD changes in any part of the brain in healthy controls were considered as false positives, absence of BOLD responses as true negatives.