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. 2014 Jul 17;5:131. doi: 10.3389/fneur.2014.00131

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Copyright © 2014 Tousseyn, Dupont, Goffin, Sunaert and Van Paesschen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sensitivity and specificity. Receiver operating characteristic (ROC)-curves using different statistical Z-score thresholds at the voxel level (range, 0–13; step-size, 0.1) and (A) no constraint on cluster size, (B) a minimal cluster extent of 350 voxels. The results were based on all EEG-fMRI activations (blue) and upon the cluster containing the maximal significant activation only (green). The orange circle corresponds to the statistical threshold of uncorrected p < 0.001 (Z = 3.1), red circles to a significance level of FWE corrected p < 0.05 (Z = 4.9–5.1). The pink circle represents Z-score thresholds of 3.4 and 3.5. Note that not every change in Z-score threshold is associated with a change in sensitivity and specificity.