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. 2014 Mar 4;7(2):188–195. doi: 10.1016/j.tranon.2014.02.003

Figure 3.

Figure 3

Single agent effect on A498 RCC xenograft tumor growth and perfusion. (A) This figure shows that trebananib (Ang1/2 inhibitor) and L1-7 (Ang2 inhibitor) slow A498 RCC tumor growth. Ang1 inhibition (mL4-3) did not alter A498 RCC tumor growth. (B, C) Representative ASL MRI images and quantitative tumor perfusion results in A498 RCC xenograft tumor model at days 0, 7, and 21 after treatment with trebananib (Ang1/2 inhibitor), L1-7 (Ang2 inhibitor), mL4-3 (Ang1 inhibitor), or Fc demonstrate significant reduction of tumor perfusion observed after Ang2 inhibition but not Ang1 inhibition alone compared with the Fc group at days 7 and 21 (P < 0.05). Data are expressed as means ± SD. Tumor regions are outlined with a red line in reference proton density images and corresponding ASL perfusion color maps. The tumor size (mm) and the mean blood flow (in ml/100 g per min) are shown below the images. The color bar beside the images represents the range of perfusion values from 0 to 160 ml/100 g per min.