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. 2014 May 6;4(2):356–375. doi: 10.3390/brainsci4020356

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© 2014 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Propofol administered to pregnant rats induced a significant loss of hippocampal neurons in the offspring rats. Quantification of the neuronal density counts in the hippocampal CA1 (A) and CA3 (B) regions of pups on postnatal day 10 (P10), and P28. Neuronal density counts were obtained from Nissl stained sections. Data from six pups per group (N = 6; 1 pup per litter, n = 6) are expressed as means ± SEM. ** p < 0.01, *** p < 0.001 significant difference from age-matched control group. (C) Representative photomicrographs of hippocampal sections stained with Nissl indicated neuron density in P28 offspring. Scale bar = 50 µm.