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. Author manuscript; available in PMC: 2014 Jul 17.
Published in final edited form as: Cell. 2014 Jan 23;156(3):495–509. doi: 10.1016/j.cell.2014.01.008

Figure 1. Maternal HFD-feeding induces pregestational metabolic abnormalities and hyperinsulinemia during lactation in the offspring.

Figure 1

Maternal (A) pregestational body weight, (B) fasted blood glucose levels and (C) homeostatic model assessment indices of insulin resistance (HOMA-IR) (n=48vs50). (D) Maternal preweaning serum insulin levels in the fed state (n=4 for all groups). (E) Serum insulin levels in the offspring at 3 weeks of age (n=9 for all groups). NCD=normal chow diet, HFD=high fat diet. Data are presented as mean ± SEM, **p < 0.01, ***p < 0.001 versus all other groups within the same diet after week 8, if not indicated otherwise. See also Figure S1 for an overview of all experimental groups.