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. Author manuscript; available in PMC: 2014 Jul 17.
Published in final edited form as: Cell. 2014 Jan 23;156(3):495–509. doi: 10.1016/j.cell.2014.01.008

Figure 2. Maternal HFD-feeding exclusively during lactation predisposes the offspring for metabolic disorders.

Figure 2

The following metabolic parameters were analyzed in all eight groups of male offspring. (A) Body weight on (i) normal chow diet (NCD; n=14vs10vs14vs13) or (ii) high fat diet (HFD; n=10vs8vs13vs12), (B) body fat content and (C) perigonadal fat pad weight at 20 weeks (nNCD=14vs10vs13vs12 and nHFD=10vs8vs12vs11), (D) fasted serum leptin levels and (E) homeostatic model assessment indices of insulin resistance (HOMA-IR) at 15 weeks (nNCD=13vs8vs11vs9 and nHFD=9vs8vs11vs11) and (F) glucose tolerance tests (GTT) at 15 weeks of age on i) NCD (n=13vs10vs14vs13) and ii) HFD (n=10vs8vs9vs12). Data are presented as mean ± SEM, *p < 0.05. **p < 0.01. ***p < 0.001 versus all other groups within the same diet after 8 weeks of age, unless otherwise indicated. See also Figure S2 for data on female offspring.