Table 1.
Metabolic parameters in SHR
| SHR | Intact-NS (10) | OVX-NS (11) | Intact-HS (14) | OVX-HS (14) |
|---|---|---|---|---|
| Body weight, g | ||||
| Baseline | 205 ± 2 | 244 ± 4† | 209 ± 3 | 243 ± 5† |
| Week 1 | 209 ± 2‡ | 265 ± 4†‡ | 223 ± 3*‡ | 267 ± 4†‡ |
| Week 2 | 217 ± 3‡ | 277 ± 4†‡ | 230 ± 2*‡ | 271 ± 4† |
| Food Intake, g/day | ||||
| Baseline | 15 ± 1 | 23 ± 1† | 19 ± 1 | 22 ± 1† |
| Week 1 | 17 ± 0 | 21 ± 2 | 18 ± 1 | 18 ± 1 |
| Week 2 | 17 ± 1 | 21 ± 0 | 17 ± 1 | 18 ± 1 |
| Water intake, ml/day | ||||
| Baseline | 28 ± 6 | 31 ± 2 | 26 ± 6 | 21 ± 1 |
| Week 1 | 31 ± 4 | 36 ± 2 | 50 ± 4*‡ | 50 ± 5*‡ |
| Week 2 | 32 ± 3 | 32 ± 3 | 50 ± 2* | 48 ± 3* |
| Urine output, ml/day | ||||
| Baseline | 20 ± 5 | 23 ± 1 | 18 ± 1 | 21 ± 2 |
| Week 1 | 24 ± 3 | 26 ± 2 | 39 ± 3*‡ | 41 ± 4*‡ |
| Week 2 | 22 ± 3 | 25 ± 2 | 48 ± 3* | 39 ± 2* |
| Urinary Na+ excretion, mmol/day | ||||
| Baseline | 0.64 ± 0.1 | 0.96 ± 0.3† | 0.78 ± 0.7 | 0.99 ± 0.1† |
| Week 1 | 0.70 ± 0.5 | 0.78 ± 0.5 | 11.73 ± 0.6*‡ | 11.66 ± 0.3*‡ |
| Week 2 | 0.76 ± 0.1 | 0.83 ± 0.1 | 11.04 ± 0.6* | 10.78 ± 0.5* |
At baseline, all rats were maintained on phytoestrogen-free normal salt diet (NS; 0.4% NaCl, Harlan Teklad). Rats were then randomized to remain on NS or were switched to phytoestrogen-free high-salt diet (HS; 4% NaCl) for an additional 2 wk. All data are expressed as means ± SE.
*
Significant difference from NS control of the same group [intact or ovariectomized (OVX)].
†
Significant difference from gonad-intact of the same treatment group (NS or HS).
‡
Significant difference from the previous week within the same group. Numbers in parentheses refer to n values.