Fig. 2.

Matrix metalloprotease (MMP) inhibitors differentially inhibit human satellite cell invasion. A–D: human satellite cell invasion in the presence of tissue inhibitors of metalloprotease-1 (TIMP-1; A), TIMP-2 (B), TIMP-3 (C), or GM6001 (D); all but TIMP-1 significantly inhibit invasion. E: quantitative comparison of human and mouse satellite cell invasion based on the fraction of cells invading beneath the surface of the collagen matrix, compared with all cells in the section (n ≥ 3). *P < 0.05. Statistically significant P values were based on comparison of protease inhibitors to the no inhibitor positive control.