Table 3.

Kinase inhibitor sensitivity profiles for top-20 kinases in Table 2

Kinase (Gene Symbol)	H-89 (1 μM)	H-89 (10 μM)	KN-93 (10 μM)	KN-62 (10 μM)	GSK-650394A (5 μM)
Camk2d*	<25	50–100	50–100	50–100	<25
Akt1	50–100	50–100	50–100	<25	25–50
Prkaca	50–100	50–100	50–100	<25	<25
Prkacb	50–100	50–100	50–100	<25	<25
Cdc42bpb*	50–100	50–100	50–100	<25	25–50
Prkcd*	25–50	25–50	25–50	<25	25–50
Cask*	<25	50–100	50–100	50–100	<25
Dapk3*	<25	50–100	<25	<25	ND
Mark2	<25	50–100	<25	<25	25–50
Mark3	<25	50–100	<25	<25	25–50
Nuak2*	50–100	50–100	<25	ND	50–100
Pdpk1	<25	<25	<25	<25	<25
Pkn1*	50–100	50–100	50–100	<25	50–100
Pkn2	50–100	50–100	50–100	<25	50–100
Prkci*	<25	50–100	<25	<25	<25
Rock2	50–100	50–100	50–100	<25	25–50
Rps6ka1	50–100	50–100	50–100	<25	<25
Camk1	<25	50–100	50–100	50–100	<25
Phkg2*	25–50	50–100	<25	<25	50–100
Camkk2	<25	<25	25–50	<25	50–100

Values represent percent inhibition. Data are from the International Centre for Kinase Profiling (Dundee, Scotland).

^*Effect was obtained from the nearest homolog: Camk1 for Camk2d, Rock2 for Cdc42bpb, Prkca for Prkcd, Camk1 for Cask, Dapk1 for Dapk3, Nuak1 for Nuak2, Pkn2 for Pkn1, Prkcz for Prkci, and Phkg1 for Phkg2.

ND, not determined.