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. 2014 Jun 4;307(2):C195–C207. doi: 10.1152/ajpcell.00293.2013

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Fig. 5. — CFTR expression and maturation. A and C: representative immunoblots showing similar CFTR expression and maturation level in tissue lysates from duodenum (A) and lung (C), from two different mice in each group: wild-type (VIP^+/+), VIP-KO (VIP^−/−), and VIP-KO mice that received intraperitoneal injections of VIP for 3 wk (VIP^−/− after treatment). Mature fully glycosylated band c and immature core-glycosylated band b are indicated by arrows. B and D: histograms showing average values from densitometry measurements of CFTR mature band c (∼180 kDa) expressed as percentage (%) of total CFTR (bands b + c) in duodenum (B) and lung (D) of wild-type, VIP-KO, and VIP-KO mice treated with VIP. ns, not statistically significant. E: negative control immunoblot showing the absence of CFTR signal in tissue lysates from CFTR-KO duodenum and CFTR-KO lung as indicated. Tissue lysates from 5 mice in each group were analyzed and used to calculate average densitometry ratios.