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Effects of megalin siRNAs and/or AT1 receptor blocker losartan on ANG II-induced activation (phosphorylation) of NHE3 in AT1a-KO mPCT cells. AT1a-KO mPCT cells pretransfected with or without megalin siRNAs or pretreated with losartan for 48 h were incubated with ANG II (10 nM) at 37°C for 1 h before proteins were extracted for Western blots of total and phosphorylated NHE3 proteins. No significant effects of ANG II, megalin siRNA, or losartan were observed in AT1a-KO mPCT cells.
