Fig. 1.
A: isometric tension recordings demonstrating responsiveness of isolated rings of fetal coronary artery to bradykinin. Arterial rings were contracted with 9,11-dideoxy-11α,9α-epoxymethano-PGF2α (U46619), followed by cumulative addition of bradykinin at the time points marked by arrowheads. B: log concentration-response curves for bradykinin in producing relaxations of isolated fetal coronary arteries from ewes fed a control (100%) or nutrient-restricted (60%) diet during the last ⅔ of pregnancy. Data are expressed as a percentage of the initial increase in tension induced by U46619 (3 × 10−9 M), which averaged 2.22 ± 0.3 and 2.38 ± 0.2 g in fetal coronary arteries from ewes fed a control and nutrient-restricted diet, respectively (P > 0.05). Each point represents the mean ± SE; n = 6.