Table 1.
Morphometric values and plasma biochemistry of APOE2 knock-in mice fed WD for 12 wk
| Parameter | NGT | INS | IGT |
|---|---|---|---|
| n | 4 | 4 | 5 |
| Body weight (g) | 47.1 ± 2.9 | 48.9 ± 1.9 | 46.5 ± 1.2 |
| Insulin | 1.36 ± 0.07# | 2.93 ± 0.19 | 1.75 ± 0.16# |
| Glucose (mg/dl) | 130 ± 11 | 155 ± 6¶ | 205 ± 7* |
| AUC | 23,192 ± 768 | 27,401 ± 358 | 35,812 ± 2369* |
| Triglycerides (mg/dl) | 301 ± 34 | 268 ± 9 | 312 ± 28 |
| Cholesterol (mg/dl) | 526 ± 60 | 495 ± 14 | 531 ± 34 |
| NEFA (meq/L) | 0.60 ± 0.10 | 0.75 ± 0.10 | 0.62 ± 0.08 |
| Adiponectin (μg/ml) | 27.10 ± 3.43 | 27.82 ± 2.88 | 27.38 ± 1.73 |
| Visceral fat (g) | 1.96 ± 0.18 | 2.28 ± 0.21 | 2.11 ± 0.15 |
| Subcutaneous fat (g) | 2.38 ± 0.30 | 2.37 ± 0.33 | 1.98 ± 0.28 |
| Liver fat (mg triglyceride/mg protein) | 1.03 ± 0.32 | 1.06 ± 0.20 | 1.49 ± 0.34 |
| Visceral/subcutaneous ratio | 0.835 ± 0.040 | 0.985 ± 0.061 | 1.125 ± 0.115¶ |
| Aortic lesion (μm2×100) | 919 ± 177 | 1370 ± 353 | 3513 ± 2369¶ |
Values are means ± sem.
*
P < 0.05 vs. INS;
¶
P < 0.05 vs. NGT;
#
P < 0.05 vs. NGT and INS.