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Transient receptor potential vanilloid type 1 (TRPV1) antagonist AMG-9810 inhibited the acid-evoked currents in nodose and jugular neurons in a dose-dependent manner. A–D: AMG-9810 significantly inhibited acid (pH 4.4)-evoked current in both nodose and jugular neurons (***P < 0.001). E and F: dose-dependence curve of the inhibition effects of AMG-9810 on acid-induced currents in nodose and jugular neurons from naïve guinea pigs. ***P < 0.001 for pH 4.4 vs. pH 4.4 + AMG-9810.
