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Activation of HIF-1α does not increase tumor formation in a mouse model of CAC. Tumor counting in the colons (A), representative colon tumor H&E staining (B), and representative colon tumor BrdU and cCasp3 staining (C) and quantitation (D) from Hif-1αLSL/LSL and Hif-1α+/+ mice following AOM/DSS model of colon cancer. 5–8 mice were assessed per each group; NS; not significant.
