Table 2.
List of upregulated genes from the colons of Hif-1αLSL/LSL vs. Hif-1α+/+ mice
| Symbol | Description |
|---|---|
| Bnip3 (45) | Bcl2/adenovirus E1B-interacting protein 3 |
| Ndufa4l2 (50) | NADH dehydrogenase (ubiquinone) 1 α-subcomplex, 4-like 2 |
| Slc16a3 | Solute carrier family 16 (monocarboxylic acid transporters), member 3 |
| Shmt2 | Serine hydroxymethyltransferase 2 (mitochondrial) |
| Ak4 | Adenylate kinase 4 |
| Myl7 | Myosin, light polypeptide 7, regulatory |
| Pfkfb3 (36) | 6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 |
| Nrn1 | Neuritin 1 |
| P4 ha1 (15) | Procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), α1 polypeptide |
| Stc2 (33) | Stanniocalcin 2 |
| Lpo | Lactoperoxidase |
| Greb1 | Gene regulated by estrogen in breast cancer protein |
| Mif (1) | Macrophage migration inhibitory factor |
| Pdk1 (30) | Pyruvate dehydrogenase kinase, isoenzyme 1 |
| Plod2 (16) | Procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 |
| Car9 (51) | Carbonic anhydrase 9 |
| Grin1 | Glutamate receptor, ionotropic, NMDA1 (ζ1) |
| Itga7 | Integrin α7 |
| Plod1 (16) | Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 |
| Rgs11 | Regulator of G protein signaling 11 |
| Aldoc (23) | Aldolase C, fructose-bisphosphate |
| Eltd1 | EGF, latrophilin 7 transmembrane domain containing 1 |
| Higd1a | HIG1 domain family, member 1A |
| Fam162a (31) | Family with sequence similarity 162, member A |
| Egln3 (4) | Egl 9 homolog 3 (C. elegans) |
| Pgk1 (43) | Phosphoglycerate kinase 1 |
| Hmox1 (32) | Heme oxygenase (decycling) 1 |
| P4 ha2 (15) | Procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), αII polypeptide |
| Cmah | Cytidine monophospho-N-acetylneuraminic acid hydroxylase |
| Krt84 | Krt84 keratin 84 |
| Eno1 (43) | Enolase 1, α nonneuron |
| 5730507C01Rik | RIKEN cDNA 5730507C01 gene |
| 1700057G04Rik | RIKEN cDNA 1700057G04 gene |
| Ero1l (14) | ERO1-like (S. cerevisiae) |
Bold font indicates known hypoxia-inducible factor (HIF)-1α target genes with the subsequent reference.