Figure 1.

Flowchart of CIA. The gene expression matrix (blue) contains the genes in the rows and the conditions in the columns. The protein expression matrix (orange) contains the proteins in the rows and the conditions in the columns. The conditions in our study correspond to the life cycle stages of P. falciparum. Genes and proteins annotated to the considered GO terms are gathered in a separate matrix (gray). The gene and the protein expression matrices are transformed into a new hyperspace. The pair maximizing the covariance is computed from the axes spanning the two hyperspaces. These two axes (gene and proteins co-inertia axes) span a new space where the conditions (life cycle stages) can be plotted. Additionally, GO terms can be projected into the CIA space and visualized together with the life cycle stages. Figure adapted from [30].