Table 4.
Characteristics of patients with tumors larger than 3 cm
| Variables | Group A3 (n = 163) | Group B3 (n = 230) | P -value |
|---|---|---|---|
| Age (range) |
51.90 ± 10.14 |
54.59 ± 9.69 |
0.008 |
| Gender (male/female) |
131/32 (80.4/19.6%) |
177/53 (77.0/23.0%) |
0.418 |
| Etiology |
|
|
0.085 |
| HBV |
125 (76.7%) |
176 (76.5%) |
|
| HCV |
2 (1.2%) |
12 (5.2%) |
|
| both |
1 (0.6%) |
3 (1.3%) |
|
| alcohol |
7 (4.3%) |
3 (1.3%) |
|
| idiopathic |
28 (17.2%) |
36 (15.7%) |
|
| Child-Pugh classification |
|
|
0.653 |
| A/B |
160/3 (98.2/1.8%) |
228/2 (99.1/0.9%) |
|
| Cirrhosis |
66 (40.5%) |
114 (49.6%) |
0.075 |
| Serum albumin ≤ 3.5 g/dL |
39 (24.1%) |
25 (10.9%) |
< 0.001 |
| AST (IU/L) > 50 |
31 (19.1%) |
56 (24.3%) |
0.221 |
| ALT (IU/L) > 50 |
38 (23.5%) |
56 (24.3%) |
0.839 |
| Operation |
|
|
0.004 |
| minor/major operation |
87/76 (53.4/46.6%) |
89/141 (38.7/61.3%) |
|
| Perioperative bleeding |
|
|
0.131 |
| ≤ 1,000 cc/>1,000 cc |
103/60 (63.2/36.8%) |
162/68 (70.4/29.6%) |
|
| Perioperative transfusion |
109 (66.9%) |
79 (34.3%) |
< 0.001 |
| Perioperative complication |
51 (31.3%) |
61 (26.5%) |
0.302 |
| Perioperative mortality |
5 (3.1%) |
5 (2.2%) |
0.747 |
| Resection margin |
|
|
0.002 |
| ≤ 1 cm/>1 cm |
79/72 (52.3/47.7%) |
83/144 (36.6/63.4%) |
|
| Histologic differentiation |
|
|
0.073 |
| Edmondson-Steiner grade III to IV |
57 (35.0%) |
57 (24.8%) |
|
| AFP (IU/mL) |
4,129.58 ± 11,213.53 |
3,086.58 ± 10,003.07 |
0.334 |
| Multiple tumors |
45 (27.6%) |
38 (16.5%) |
0.008 |
| Gross vascular invasion |
10 (6.1%) |
22 (9.6%) |
0.746 |
| Microscopic vascular invasion | 103 (63.2%) | 111 (48.3%) | 0.003 |
AFP, alpha-fetoprotein; ALT, alanine aminotransferase; AST, aspartate aminotransferase; HBV, hepatitis B virus; HCV, hepatitis C virus.