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. 2014 Mar 3;3(3):643–651. doi: 10.1002/cam4.218

Table 2.

Characteristics of resected hepatocellular carcinoma specimens according to elevations of conventional or highly sensitive AFP-L3 after hepatectomy (n = 187)

Conventional AFP-L3 Highly sensitive AFP-L3


Negative (n = 174) Positive (n = 13) Negative (n = 89) Positive (n = 98)
Child-Pugh class (A/B) 166 (95.4)/8 (4.6) 13 (100)/0 87 (97.8)/2 (2.2) 92 (93.9)/6 (6.1)
Tumor size (cm) 3.09 ± 2.30a 5.19 ± 4.21a 3.28 ± 2.56 3.20 ± 2.50
Number of tumors (single/multiple) 143 (82.2)/31 (17.8) 10 (76.9)/3 (23.1) 73 (82.0)/16 (18.0) 80 (81.6)/18 (18.4)
Differentiation (well-/moderately or poorly) 52 (29.9)/122 (70.1)2 0/13 (100)b 25 (29.1)/64 (71.9) 27 (27.6)/71 (72.4)
Growth pattern (expansive/infiltrative) 161 (92.5)/13 (7.5)c 9 (69.2)/4 (30.8)c 81 (91.0)/8 (9.0) 89 (90.8)/9 (9.2)
Capsular formation (absent/present)1 62 (38.5)/99 (61.5) 2 (22.2)/7 (77.8) 28 (34.6)/53 (65.4) 36 (40.4)/53 (59.6)
Capsular infiltration (absent/present)2 38 (38.4)/61 (61.6) 1 (14.3)/6 (85.7) 23 (43.4)/30 (56.6) 16 (30.2)/37 (69.8)
Portal vein invasion (absent/present)3 146 (83.9)/28 (16.1) 8 (61.5)/5 (38.5) 69 (77.5)/20 (22.5) 85 (86.7)/13 (13.3)

Unless otherwise indicated, values are means ± SD and percentages are indicated in parentheses. aP = 0.0143, bP = 0.0454, cP = 0.0203.

1

Evaluated only in HCC with expansive growth.

2

Evaluated only in HCC with capsular formation.

3

On pathologic evaluation.